Livestock Susceptibility to Infection with Middle East Respiratory Syndrome Coronavirus
Identifieur interne : 000D18 ( Main/Exploration ); précédent : 000D17; suivant : 000D19Livestock Susceptibility to Infection with Middle East Respiratory Syndrome Coronavirus
Auteurs : Júlia Vergara-Alert ; Judith M. A. Van Den Brand ; W. Widagdo ; Marta Mu Oz ; Stalin Raj ; Debby Schipper ; David Solanes ; Ivan Cord N ; Albert Bensaid ; Bart L. Haagmans ; Joaquim SegalésSource :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2017.
Descripteurs français
- KwdFr :
- ARN viral, Animaux, Bétail (virologie), Cellules Vero, Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Equus caballus, Immunité humorale, Infections à coronavirus (médecine vétérinaire), Maladies de l'animal (diagnostic), Maladies de l'animal (virologie), Maladies de l'animal (épidémiologie), Ovis, Réservoirs d'agents pathogènes, Suidae, Surveillance de la santé publique, Susceptibilité à une maladie, Test ELISA, Tests de neutralisation.
- MESH :
- diagnostic : Maladies de l'animal.
- médecine vétérinaire : Infections à coronavirus.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Bétail, Maladies de l'animal.
- épidémiologie : Maladies de l'animal.
- ARN viral, Animaux, Cellules Vero, Equus caballus, Immunité humorale, Ovis, Réservoirs d'agents pathogènes, Suidae, Surveillance de la santé publique, Susceptibilité à une maladie, Test ELISA, Tests de neutralisation.
English descriptors
- KwdEn :
- Animal Diseases (diagnosis), Animal Diseases (epidemiology), Animal Diseases (virology), Animals, Chlorocebus aethiops, Coronavirus Infections (veterinary), Disease Reservoirs, Disease Susceptibility, Enzyme-Linked Immunosorbent Assay, Horses, Immunity, Humoral, Livestock (virology), Middle East Respiratory Syndrome Coronavirus (physiology), Neutralization Tests, Public Health Surveillance, RNA, Viral, Sheep, Swine, Vero Cells.
- MESH :
- chemical : RNA, Viral.
- diagnosis : Animal Diseases.
- epidemiology : Animal Diseases.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- veterinary : Coronavirus Infections.
- virology : Animal Diseases, Livestock.
- Animals, Chlorocebus aethiops, Disease Reservoirs, Disease Susceptibility, Enzyme-Linked Immunosorbent Assay, Horses, Immunity, Humoral, Neutralization Tests, Public Health Surveillance, Sheep, Swine, Vero Cells.
Abstract
Middle East respiratory syndrome (MERS) cases continue to be reported, predominantly in Saudi Arabia and occasionally other countries. Although dromedaries are the main reservoir, other animal species might be susceptible to MERS coronavirus (MERS-CoV) infection and potentially serve as reservoirs. To determine whether other animals are potential reservoirs, we inoculated MERS-CoV into llamas, pigs, sheep, and horses and collected nasal and rectal swab samples at various times. The presence of MERS-CoV in the nose of pigs and llamas was confirmed by PCR, titration of infectious virus, immunohistochemistry, and in situ hybridization; seroconversion was detected in animals of both species. Conversely, in sheep and horses, virus-specific antibodies did not develop and no evidence of viral replication in the upper respiratory tract was found. These results prove the susceptibility of llamas and pigs to MERS-CoV infection. Thus, the possibility of MERS-CoV circulation in animals other than dromedaries, such as llamas and pigs, is not negligible.
Url:
DOI: 10.3201/eid2302.161239
PubMed: 27901465
PubMed Central: 5324816
Affiliations:
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A." last="Van Den Brand">Judith M. A. Van Den Brand</name></author><author><name sortKey="Widagdo, W" sort="Widagdo, W" uniqKey="Widagdo W" first="W." last="Widagdo">W. Widagdo</name></author><author><name sortKey="Mu Oz, Marta" sort="Mu Oz, Marta" uniqKey="Mu Oz M" first="Marta" last="Mu Oz">Marta Mu Oz</name></author><author><name sortKey="Raj, Stalin" sort="Raj, Stalin" uniqKey="Raj S" first="Stalin" last="Raj">Stalin Raj</name></author><author><name sortKey="Schipper, Debby" sort="Schipper, Debby" uniqKey="Schipper D" first="Debby" last="Schipper">Debby Schipper</name></author><author><name sortKey="Solanes, David" sort="Solanes, David" uniqKey="Solanes D" first="David" last="Solanes">David Solanes</name></author><author><name sortKey="Cord N, Ivan" sort="Cord N, Ivan" uniqKey="Cord N I" first="Ivan" last="Cord N">Ivan Cord N</name></author><author><name sortKey="Bensaid, Albert" sort="Bensaid, Albert" uniqKey="Bensaid A" first="Albert" last="Bensaid">Albert Bensaid</name></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name></author><author><name sortKey="Segales, Joaquim" sort="Segales, Joaquim" uniqKey="Segales J" first="Joaquim" last="Segalés">Joaquim Segalés</name></author></analytic><series><title level="j">Emerging Infectious Diseases</title><idno type="ISSN">1080-6040</idno><idno type="eISSN">1080-6059</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal Diseases (diagnosis)</term><term>Animal Diseases (epidemiology)</term><term>Animal Diseases (virology)</term><term>Animals</term><term>Chlorocebus aethiops</term><term>Coronavirus Infections (veterinary)</term><term>Disease Reservoirs</term><term>Disease Susceptibility</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Horses</term><term>Immunity, Humoral</term><term>Livestock (virology)</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Neutralization Tests</term><term>Public Health Surveillance</term><term>RNA, Viral</term><term>Sheep</term><term>Swine</term><term>Vero Cells</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral</term><term>Animaux</term><term>Bétail (virologie)</term><term>Cellules Vero</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Equus caballus</term><term>Immunité humorale</term><term>Infections à coronavirus (médecine vétérinaire)</term><term>Maladies de l'animal (diagnostic)</term><term>Maladies de l'animal (virologie)</term><term>Maladies de l'animal (épidémiologie)</term><term>Ovis</term><term>Réservoirs d'agents pathogènes</term><term>Suidae</term><term>Surveillance de la santé publique</term><term>Susceptibilité à une maladie</term><term>Test ELISA</term><term>Tests de neutralisation</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Animal Diseases</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maladies de l'animal</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Animal Diseases</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Bétail</term><term>Maladies de l'animal</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Animal Diseases</term><term>Livestock</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Maladies de l'animal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Disease Reservoirs</term><term>Disease Susceptibility</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Horses</term><term>Immunity, Humoral</term><term>Neutralization Tests</term><term>Public Health Surveillance</term><term>Sheep</term><term>Swine</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ARN viral</term><term>Animaux</term><term>Cellules Vero</term><term>Equus caballus</term><term>Immunité humorale</term><term>Ovis</term><term>Réservoirs d'agents pathogènes</term><term>Suidae</term><term>Surveillance de la santé publique</term><term>Susceptibilité à une maladie</term><term>Test ELISA</term><term>Tests de neutralisation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome (MERS) cases continue to be reported, predominantly in Saudi Arabia and occasionally other countries. Although dromedaries are the main reservoir, other animal species might be susceptible to MERS coronavirus (MERS-CoV) infection and potentially serve as reservoirs. To determine whether other animals are potential reservoirs, we inoculated MERS-CoV into llamas, pigs, sheep, and horses and collected nasal and rectal swab samples at various times. The presence of MERS-CoV in the nose of pigs and llamas was confirmed by PCR, titration of infectious virus, immunohistochemistry, and in situ hybridization; seroconversion was detected in animals of both species. Conversely, in sheep and horses, virus-specific antibodies did not develop and no evidence of viral replication in the upper respiratory tract was found. These results prove the susceptibility of llamas and pigs to MERS-CoV infection. Thus, the possibility of MERS-CoV circulation in animals other than dromedaries, such as llamas and pigs, is not negligible.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bensaid, Albert" sort="Bensaid, Albert" uniqKey="Bensaid A" first="Albert" last="Bensaid">Albert Bensaid</name><name sortKey="Cord N, Ivan" sort="Cord N, Ivan" uniqKey="Cord N I" first="Ivan" last="Cord N">Ivan Cord N</name><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name><name sortKey="Mu Oz, Marta" sort="Mu Oz, Marta" uniqKey="Mu Oz M" first="Marta" last="Mu Oz">Marta Mu Oz</name><name sortKey="Raj, Stalin" sort="Raj, Stalin" uniqKey="Raj S" first="Stalin" last="Raj">Stalin Raj</name><name sortKey="Schipper, Debby" sort="Schipper, Debby" uniqKey="Schipper D" first="Debby" last="Schipper">Debby Schipper</name><name sortKey="Segales, Joaquim" sort="Segales, Joaquim" uniqKey="Segales J" first="Joaquim" last="Segalés">Joaquim Segalés</name><name sortKey="Solanes, David" sort="Solanes, David" uniqKey="Solanes D" first="David" last="Solanes">David Solanes</name><name sortKey="Van Den Brand, Judith M A" sort="Van Den Brand, Judith M A" uniqKey="Van Den Brand J" first="Judith M. A." last="Van Den Brand">Judith M. A. Van Den Brand</name><name sortKey="Vergara Alert, Julia" sort="Vergara Alert, Julia" uniqKey="Vergara Alert J" first="Júlia" last="Vergara-Alert">Júlia Vergara-Alert</name><name sortKey="Widagdo, W" sort="Widagdo, W" uniqKey="Widagdo W" first="W." last="Widagdo">W. Widagdo</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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